Longevity Command Center
Module 01
Module 02
Atherogenic Particles
Glycemic Control
Renal Function
Androgen Axis
Liver — GGT
Hematology — Hgb/Hct
Module 03
Your blood lipid profile shows a mismatch between two different ways of measuring heart risk:
- Your ApoB is 108 mg/dL (ideal <80) and your Lp(a) is 90 nmol/L (ideal <75) — both elevated.
- But your CAC score is 0 (best possible) — no calcified hardening yet.
A persistent yeast infection in warm/moist skinfolds (groin and armpits) that was misdiagnosed for months as common "jock itch."
A small benign-but-precancerous polyp was found and removed during your 2024 screening colonoscopy. Located at the hepatic flexure — the bend in the colon near the liver.
A varicocele is essentially a varicose vein in the scrotum — the small veins that drain blood from the testicle become dilated and tortuous. Yours was surgically repaired in ~2008 but has recurred. Ultrasound confirmed both testes are normal in size, mildly heterogeneous tissue, no masses. A small (5 mm) benign cyst in the left epididymal head — common incidental finding.
GGT has been mildly elevated in every test for 3+ years (~50% above the upper limit). Your other liver enzymes — ALT and AST — are completely normal. Isolated GGT elevation without ALT/AST rise points away from classic hepatitis or fatty liver.
When you got your heart-calcium scan, the radiologist noticed a tiny 2 mm spot in the lung (lingula area). Incidental lung findings on chest CT are very common.
Age-related decline in the lens's ability to focus on close objects combined with a slight irregular curvature of the cornea. Both common; both correctable with glasses.
Prescription: both eyes +1.25 / -0.50 × 085.
Either descended on its own in early childhood or was surgically positioned. Current ultrasound (Mar 2026) confirms both testes are normal size with no concerning features.
Module 04
| Screen / Test | Last Done | Cadence | Next Due | Status | Rationale |
|---|---|---|---|---|---|
| Lipid + ApoB + Lp(a) | 17 Mar 2026 | Quarterly (active workup) | ~Jun 2026 | on track | Lp(a) requires LC-MS or isoform-indep assay in nmol/L; reflex at draw |
| Comprehensive Hormone Panel | 17 Mar 2026 | 3-month on CJC/Ipa | ~17 Jul 2026 | on track | SHBG, Free T, LH, E2, IGF-1, DHEA-S, PSA |
| IGF-1 (early on-cycle check) | 17 Mar 2026 (pre-cycle) | 4–6 wk after start | ~22 May 2026 | due now | Confirm response; stop if >300 ng/mL. Order via questhealth.com |
| Fasting Ferritin + Iron/TIBC | Never | Baseline → annual if normal | Immediately | overdue | HFE H63D carrier + 3-yr GGT elevation; HIGH priority |
| Vitamin D 25-OH | 09 Apr 2024 (28.9 ng/mL, low) | Annual | Overdue (2 yr) | overdue | Was deficient; supplementing 3000 IU/day; need to verify response |
| Methylation Panel (Hcy, MMA, B12, Folate RBC) | Never | One-off baseline | Next draw | pending | MTHFR A1298C homozygous; gates 5-MTHF dosing decision |
| Cystatin C | Never | One-off | Next draw | pending | True GFR — not confounded by muscle/creatine |
| Surveillance Colonoscopy | 06 Jun 2024 (adenoma resected) | Every 3 yr (post-adenoma) | ~Jun 2027 | scheduled-ready | 3-year protocol — book by Q1 2027 |
| Cardiac CAC Scan | 07 Aug 2024 (score = 0) | Every 3–5 yr | 2027–2029 | on track | Score = 0 = low yield short-term. Consider CCTA instead next cycle. |
| CCTA (Coronary CT Angiography) | Never | Once, then as needed | Consider in 2026 | discussion | Your CAC = 0 is reassuring but doesn't see soft plaque (which Lp(a) drives). CCTA shows the full picture. |
| Full Body Derm Exam | Unknown / overdue | Annual | ASAP | verify | Standard for 48-yo male; not in current records |
| Ophthalmology (incl. macular OCT) | ~Feb 2026 (Rx visit) | Annual | ~Feb 2027 | on track | AMD PRS Z=1.91 above-average — OCT for early macular changes |
| DEXA scan (body composition + bone density) | Never | Every 2 yr | Consider 2026 | discussion | Establishes pre-CJC baseline for body composition tracking; also bone density check given above-average osteoarthritis genetic risk. |
| VO₂max / CPET test | Never | Annual | 2026 | discussion | The strongest single predictor of all-cause mortality. No Zone 2 or VO₂ data on file currently. |
| Sleep Study (if Hct rises further) | Never | PRN | PRN | conditional | Trigger: Hct >48% or symptomatic sleep disturbance |
Module 05
Titration: Wk 1–2: 100 mcg → Wk 3–4: 150 mcg → Wk 5–6: 200 mcg → Wk 7–12: 250–300 mcg of each peptide.
Module 06
| Supplement | Dose | Evidence | Status | Mechanism / Rationale | Monitoring |
|---|---|---|---|---|---|
| Psyllium Husk NOW Foods or Yerba Prima — unflavored |
10 g/day (titrate from 5 g) | strong | ADD — high priority | Forms a gel that grabs bile acids and pulls them out via stool. Liver responds by pulling cholesterol from blood → ApoB drops. Bonus: slows sugar absorption (HbA1c down 0.2–0.4%), counteracting the mild HbA1c rise from CJC. | ApoB, LDL, HbA1c at 8 wk |
| Plant Stanols (sitostanol esters) Benecol capsules · stanols preferred over sterols |
2 g/day with largest meal | strong (109 RCTs, EAS endorsed) | ADD — recommended | Physically displaces dietary cholesterol from being absorbed in the gut. ~10% LDL drop, 5–8% ApoB drop, small Lp(a) signal. Your ABCG5/G8 genes = wild-type. | ApoB, LDL, Lp(a), HbA1c at 12 wk |
| Creatine Monohydrate | 5 g/day (reduced from 10 g) | strong | keep | Cellular energy buffer that improves strength, power output, cognition. 5 g/day fully saturates muscle stores — 10 g was inflating creatinine without extra benefit. | Creatinine (artifact resolved) |
| Magnesium Bisglycinate CA Gold TRAACS | 200 mg/day | strong | keep | Cofactor for ~300 enzymes including those involved in insulin signaling, sleep regulation, and heart rhythm. Especially relevant given your HbA1c trending upward. | HbA1c, fasting glucose |
| Vitamin D3 CA Gold + fish-oil D | ~3,000 IU/day total | strong | keep | Critical for bone health, immune regulation, mood, and lipid metabolism. Your last test (Apr 2024) showed deficiency at 28.9 ng/mL — needs re-checking. | 25-OH Vit D — OVERDUE |
| B-Complex Plus (active forms) Seeking Health · Quatrefolic 5-MTHF + methylcobalamin | 1 cap/day | moderate | keep | You're homozygous for MTHFR A1298C, a common gene variant that makes it harder to activate folate. Active forms bypass the bottleneck entirely. | Methylation panel pending |
| N-Acetylcysteine (NAC) Nutricost | 600 mg evening only | moderate | conditional | Precursor to glutathione, your body's main antioxidant. Particularly relevant given your HFE iron-absorption variant. Take ≥6–8 hours after workouts — antioxidants right after exercise blunt the muscle-building signal. | GGT, ferritin |
| Omega-3 Fish Oil NOW Ultra · 600 EPA / 300 DHA | ~900 mg combined | subtherapeutic | restructure | The cardiovascular benefit shows up at 2–4 g/day of EPA — you're at about a quarter of that. Triglycerides already excellent. Decision: increase to ≥4 g EPA daily, or discontinue. | Omega-3 index (not measured) |
| DHEA 50 mg | — | moderate | stop now | DHEA converts partly to estrogen. Pause until 3-month hormone panel; restart only if DHEA-S drops below 200 µg/dL. | DHEA-S, E2 |
| Boron 10 mg | — | weak (single small study) | finish bottle, drop | The case for boron lowering SHBG comes from a single 8-person study — very thin evidence. CJC/Ipa addresses SHBG through a much stronger mechanism. Boron becomes redundant. | SHBG |
| TUDCA 500 mg Tauroursodeoxycholic acid | — | moderate | pause pending ferritin | Supports liver bile flow and may reduce hepatic stress. But if your GGT elevation is iron-mediated (most likely), TUDCA treats the symptom not the cause. Hold until ferritin result clarifies. | GGT, ferritin |
| 5-MTHF standalone + Methylcobalamin SL | — | — | do not add yet | Wait for methylation panel — need to see homocysteine, MMA, B12, and Folate (RBC) levels first. | — |
Module 07
UPB1 · β-ureidopropionase deficiency
FANCI · Fanconi anemia group I
SPG7 · Spastic paraplegia type 7
USH2A · Usher syndrome type 2A
HFE H63D · Hemochromatosis (see above — clinically actionable)
Module 08
Module 09
| Calisthenics (bodyweight strength) | ≥2×/week on |
| Yoga | Most days on |
| Zone 2 cardio | No data gap |
| VO₂max intervals | No data gap |
| Resistance training volume | Calisthenics-based verify |
| Protein | Target ≥1.6 g/kg = ~120 g/day |
| Pre-CJC fast | ≥2 h before bedtime injection |
| Alcohol | Minimal — GGT/HFE rationale |
| Sleep target | 7.5 h · consistent timing (Oura) |
| Lp(a) lever (diet) | Saturated fat <7% kcal |